Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study-Reference-Cited by-同舟云学术

Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study

Published:2023-06-26 Issue:13 Volume:24 Page:10643
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Pessôa Rodrigo¹,de Souza Daniela Raguer Valadão¹,Nukui Youko²,Pereira Juliana²,Fernandes Lorena Abreu¹^ORCID,Marcusso Rosa Nascimento³^ORCID,de Oliveira Augusto César Penalva³^ORCID,Casseb Jorge⁴^ORCID,da Silva Duarte Alberto José⁴,Sanabani Sabri Saeed⁴⁵⁶^ORCID

Affiliation:

1. Postgraduate Program in Translational Medicine, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04039-002, Brazil

2. Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo 05403-000, Brazil

3. Department of Neurology, Emilio Ribas Institute of Infectious Diseases, São Paulo 01246-900, Brazil

4. Laboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil

5. Laboratory of Medical Investigation Unit 03, Clinics Hospital, Faculty of Medicine, University of São Paulo, São Paulo 05403-000, Brazil

6. Laboratory of Dermatology and Immunodeficiency, LIM56/03, Instituto de Medicina Tropical de São Paulo Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470 3° andar, São Paulo 05403-000, Brazil

Abstract

Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered in a patient with adult T-cell leukemia/lymphoma. Here, we describe the sRNA profile of a 30-year-old woman with ATLL at the time of diagnosis and after maintenance therapy with the aim of correlating expression levels with response to therapy.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/13/10643/pdf

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