The Role of Selenium and Manganese in the Formation, Diagnosis and Treatment of Cervical, Endometrial and Ovarian Cancer

Author:

Golara Anna1ORCID,Kozłowski Mateusz1ORCID,Guzik Paweł2,Kwiatkowski Sebastian3ORCID,Cymbaluk-Płoska Aneta1

Affiliation:

1. Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland

2. Clinical Department of Gynecology and Obstetrics, City Hospital, 35-241 Rzeszów, Poland

3. Department of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland

Abstract

Selenium (Se) and manganese (Mn) are essential micronutrients that are important elements of cell metabolism. They are involved in the composition of enzyme systems and regulate enzyme activity. Disturbances in the homeostasis of these micronutrients affect the development of many diseases and carcinogenesis, which can be linked to increased levels of oxidative stress and impaired antioxidant properties of many enzymes. Selenium has a very important function in maintaining immune-endocrine, metabolic and cellular homeostasis. Manganese, on the other hand, is important in development, digestion, reproduction, antioxidant defense, energy production, immune response and regulation of neuronal activity. We review the role of selenium and manganese and their effects on tumor growth, metastasis potential and remodeling of the microenvironment. We also describe their role as potential biomarkers in the diagnosis and the potential for the use of Se- and Mn-containing compounds in composition for the treatment of cancer of the reproductive organs.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference174 articles.

1. Kieliszek, M. (2019). Selenium–fascinating microelement, properties and sources in food. Molecules, 24.

2. Manganese: Its Role in Disease and Health;Erikson;Met. Ions Life Sci.,2019

3. Manganese metabolism in humans;Chen;Front. Biosci.,2018

4. Selenium;Kieliszek;Advances in Food and Nutrition Research,2021

5. Selenium—A fascinating antioxidant of protective properties;Kielczykowska;Adv. Clin. Exp. Med.,2018

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