Imiquimod as Local Immunotherapy in the Management of Premalignant Cutaneous Conditions and Skin Cancer

Author:

Garcia-Mouronte Emilio1ORCID,Berna-Rico Emilio1ORCID,de Nicolas-Ruanes Belen1,Azcarraga-Llobet Carlos1,Alonso-Martinez de Salinas Luis1,Bea-Ardebol Sonia1

Affiliation:

1. Dermatology Department, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain

Abstract

Cutaneous cancers are, by far, the most common malignant neoplasms of the human being. Due to the great array of clinical conditions, their worldwide increasing incidence and the steady ageing of the population, non-invasive treatments modalities that show a good clinical response, a proper benefit–risk ratio and cosmetic results are becoming increasingly important in the clinical setting. Imiquimod is a topically applied immunomodulator which is often used in the management of several premalignant and malignant cutaneous disorders. This article is a review of the current literature on its mechanism of action, pharmacokinetics, and therapeutical effects.

Funder

Instituto de Salud Carlos III MINECO and Peder Funds

Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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