Author:
Pan Ruili,Wang Linlin,Xu Xiaopeng,Chen Ying,Wang Haojue,Wang Gang,Zhao Jianxin,Chen Wei
Abstract
Chronic constipation (CC) is a highly prevalent and burdensome gastrointestinal disorder. Accumulating evidence highlights the link between imbalances in the gut microbiome and constipation. However, the mechanisms by which the microbiome and microbial metabolites affect gut movement remain poorly understood. In this review, we discuss recent studies on the alteration in the gut microbiota in patients with CC and the effectiveness of probiotics in treating gut motility disorder. We highlight the mechanisms that explain how the gut microbiome and its metabolism are linked to gut movement and how intestinal microecological interventions may counteract these changes based on the enteric nervous system, the central nervous system, the immune function, and the ability to modify intestinal secretion and the hormonal milieu. In particular, microbiota-based approaches that modulate the levels of short-chain fatty acids and tryptophan catabolites or that target the 5-hydroxytryptamine and Toll-like receptor pathways may hold therapeutic promise. Finally, we discuss the existing limitations of microecological management in treating constipation and suggest feasible directions for future research.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province
Subject
Food Science,Nutrition and Dietetics
Cited by
19 articles.
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