Abstract
Human adenovirus (HAdV) is extremely common and can rapidly spread in confined populations such as daycare centers, hospitals, and retirement homes. Although HAdV usually causes only minor illness in otherwise healthy patients, HAdV can cause significant morbidity and mortality in certain populations, such as the very young, very old, or immunocompromised individuals. During infection, the viral DNA undergoes dramatic changes in nucleoprotein structure that promote the rapid expression of viral genes, replication of the DNA, and generation of thousands of new infectious virions—each process requiring a distinct complement of virus and host-encoded proteins. In this review, we summarize our current understanding of the nucleoprotein structure of HAdV DNA during the various phases of infection, the cellular proteins implicated in mediating these changes, and the role of epigenetics in HAdV gene expression and replication.
Funder
Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Ontario Provincial Government
Subject
Virology,Infectious Diseases
Reference167 articles.
1. Benkő, M., Aoki, K., Arnberg, N., Davison, A.J., Echavarría, M., Hess, M., Jones, M.S., Kaján, G.L., Kajon, A.E., and Mittal, S.K. (2022). ICTV Virus Taxonomy Profile: Adenoviridae 2022. J. Gen. Virol., 103.
2. Isolation of a Cytopathogenic Agent from Human Adenoids Undergoing Spontaneous Degeneration in Tissue Culture;Rowe;Proc. Soc. Exp. Biol. Med.,1953
3. Recovery of new agent from patients with acute respiratory illness;Hilleman;Proc. Soc. Exp. Biol. Med.,1954
4. Spliced segments at the 5’ terminus of adenovirus 2 late mRNA;Berget;Proc. Natl. Acad. Sci. USA,1977
5. An amazing sequence arrangement at the 5’ ends of adenovirus 2 messenger RNA;Chow;Cell,1977
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