An Overview of Canine Inherited Neurological Disorders with Known Causal Variants

Author:

Cocostîrc Vlad1ORCID,Paștiu Anamaria Ioana1ORCID,Pusta Dana Liana1ORCID

Affiliation:

1. Department of Genetics and Hereditary Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania

Abstract

Hereditary neurological conditions documented in dogs encompass congenital, neonatal, and late-onset disorders, along with both progressive and non-progressive forms. In order to identify the causal variant of a disease, the main two approaches are genome-wide investigations and candidate gene investigation. Online Mendelian Inheritance in Animals currently lists 418 Mendelian disorders specific to dogs, of which 355 have their likely causal genetic variant identified. This review aims to summarize the current knowledge on the canine nervous system phenes and their genetic causal variant. It has been noted that the majority of these diseases have an autosomal recessive pattern of inheritance. Additionally, the dog breeds that are more prone to develop such diseases are the Golden Retriever, in which six inherited neurological disorders with a known causal variant have been documented, and the Belgian Shepherd, in which five such disorders have been documented. DNA tests can play a vital role in effectively managing and ultimately eradicating inherited diseases.

Funder

National Research Development Projects

the Romanian Ministry of Research, Innovation, and Digitalization

Publisher

MDPI AG

Subject

General Veterinary,Animal Science and Zoology

Reference194 articles.

1. Inherited Neurologic Disorders in the Dog;Mellersh;Vet. Clin. N. Am. Small Anim. Pract.,2014

2. Genome-Wide Association Studies;Uffelmann;Nat. Rev. Methods Primers,2021

3. Dogs Really Are Man’s Best Friend--Canine Genomics Has Applications in Veterinary and Human Medicine!;Starkey;Brief. Funct. Genom. Proteom.,2005

4. Man’s Best Friend Becomes Biology’s Best in Show: Genome Analyses in the Domestic Dog;Parker;Annu. Rev. Genet.,2010

5. Companion Animal Models of Neurological Disease;Partridge;J. Neurosci. Methods,2020

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