Affiliation:
1. Faculty of Veterinary Medicine, University of Helsinki, FIN-00014 Helsinki, Finland
Abstract
Plasma clearance of indocyanine green (ICG-CL) is an invasive method to evaluate liver dysfunction. We aimed to investigate the practicality of a noninvasive, transcutaneous, infrared-based method estimating the disappearance rate of indocyanine green (ICG-PDR). In a randomized, cross-over study, both ICG-CL and ICG-PDR were determined in eight healthy dogs while conscious and when sedated with medetomidine and medetomidine–vatinoxan. ICG-PDR was further repeated in six of the dogs to assess its repeatability. Differences were tested with repeated-measures analysis of variance and post hoc t-tests with Bonferroni corrections, while associations were evaluated by both Spearman and Pearson correlation analyses. Furthermore, repeatability was assessed by examining calculated coefficients of variation (CV). A significant decrease in ICG-CL was observed in dogs sedated with medetomidine, while no difference between conscious and sedated states was detected with ICG-PDR. Overall, correlations between ICG-CL and ICG-PDR were poor, as was the intrasubject repeatability of ICG-PDR in conscious dogs with CV consistently above 20%. While some of the results may be explained by poor signal quality for the non-invasive method, we conclude that in healthy dogs ICG-PDR performed poorly.
Subject
General Veterinary,Animal Science and Zoology
Reference19 articles.
1. Comparison of sulfobromophthalein and indocyanine green clearances in the dog;Center;Am. J. Vet. Res.,1983
2. Adverse reactions to indocyanine green: A case report and a review of the literature;Benya;Cathet. Cardiovasc. Diagn.,1989
3. Clearance of indocyanine green in dogs with partial hepatectomy, hepatic duct ligation, and passive hepatic congestion;Rakich;Am. J. Vet. Res.,1987
4. Indocyanine green disposition in healthy dogs and dogs with mild, moderate, or severe dimethylnitrosamine-induced hepatic disease;Boothe;Am. J. Vet. Res.,1992
5. Short-term effects of N-acetylcysteine and ischemic preconditioning in a canine model of hepatic ischemia-reperfusion injury;Baumann;Eur. Surg. Res.,2008