The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions

Author:

Ren Yaolin1,Zeng Yuan1ORCID,Wu Yifan1,Yu Jie1,Zhang Qian1ORCID,Xiao Xinhua12

Affiliation:

1. Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China

2. State Key Laboratory of Complex Severe and Rare Diseases, The Translational Medicine Center of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

Abstract

The incidence of type 2 diabetes is increasing every year and has become a serious public health problem. In addition to genetic factors, environmental factors in early life development are risk factors for diabetes. There is growing evidence that the gut microbiota plays an important role in glucose metabolism, and the gut microbiota of pregnant women with gestational diabetes mellitus (GDM) differs significantly from that of healthy pregnant women. This article reviews the role of maternal gut microbiota in offspring glucose metabolism. To explore the potential mechanisms by which the gut microbiota affects glucose metabolism in offspring, we summarize clinical studies and experimental animal models that support the hypothesis that the gut microbiota affects glucose metabolism in offspring from dams with GDM and discuss interventions that could improve glucose metabolism in offspring. Given that adverse pregnancy outcomes severely impact the quality of survival, reversing the deleterious effects of abnormal glucose metabolism in offspring through early intervention is important for both mothers and their offspring.

Funder

National Natural Science Foundation of China

Beijing Natural Science Foundation

Beijing Municipal Science and Technology Commission

National Key Research and Development Program of China

Scientific Activities Foundation for Selected Returned Overseas Professionals of Human Resources and Social Security Ministry, Beijing Dongcheng District Outstanding Talent Funding Project

Medical Epigenetics Research Center, Chinese Academy of Medical Sciences

the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences

National High Level Hospital Clinical Research Funding

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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