Major and Trace Elements in Human Kidney Stones: A Preliminary Investigation in Beijing, China

Abstract

Kidney stone disease affects people globally, with its prevalence on the rise. Given the importance of elements’ function in formation of kidney stones, this study investigated major and trace element content in thirty kidney stone samples from patients in Beijing. The kidney stone samples included inorganic components (calcium oxalate and carbonate apatite) and organic components (uric acid). Results showed that Ca is much higher in inorganic components than organic components. Compared to inorganic components, uric acid has a very low content of elements except for Cu and Se, which may be derived from the liver. Carbonate apatite stones have a higher element content (such as Na, K, Sr, Zn, Rb, Ba, Li, and Ti) than calcium oxalate stones, especially enrichment of Mg. The principal components analysis (PCA) extracted three principal components (PCs) with total variances of 91.91%, including the PC1 (45.08%): Na-Li-Ti-Ba-Sr-Zn, PC2 (30.05%): Rb, K, Mg, and PC3 (16.78%): Cu-Se, indicating that there are co-precipitated processes of these elements by their specific properties. A different distribution of stone types in the three components indicates a significant discrepancy in their element content, which can be an essential reference for patient intake elements.