Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

Author:

Wu Qingyu1ORCID

Affiliation:

1. Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou 215123, China

Abstract

Endometrial decidualization is a uterine process essential for spiral artery remodeling, embryo implantation, and trophoblast invasion. Defects in endometrial decidualization and spiral artery remodeling are important contributing factors in preeclampsia, a major disorder in pregnancy. Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood volume and pressure. ANP is also generated in non-cardiac tissues, such as the uterus and placenta. In recent human genome-wide association studies, multiple loci with genes involved in natriuretic peptide signaling are associated with gestational hypertension and preeclampsia. In cellular experiments and mouse models, uterine ANP has been shown to stimulate endometrial decidualization, increase TNF-related apoptosis-inducing ligand expression and secretion, and enhance apoptosis in arterial smooth muscle cells and endothelial cells. In placental trophoblasts, ANP stimulates adenosine 5′-monophosphate-activated protein kinase and the mammalian target of rapamycin complex 1 signaling, leading to autophagy inhibition and protein kinase N3 upregulation, thereby increasing trophoblast invasiveness. ANP deficiency impairs endometrial decidualization and spiral artery remodeling, causing a preeclampsia-like phenotype in mice. These findings indicate the importance of natriuretic peptide signaling in pregnancy. This review discusses the role of ANP in uterine biology and potential implications of impaired ANP signaling in preeclampsia.

Funder

Priority Academic Program Development of Jiangsu Higher Education Institutes

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference142 articles.

1. Pre-eclampsia;Dimitriadis;Nat. Rev. Dis. Primers,2023

2. Preeclampsia;Magee;N. Engl. J. Med.,2022

3. Global and regional estimates of preeclampsia and eclampsia: A systematic review;Abalos;Eur. J. Obstet. Gynecol. Reprod. Biol.,2013

4. Pre-eclampsia: Pathophysiology and clinical implications;Burton;BMJ,2019

5. Latest advances in understanding preeclampsia;Redman;Science,2005

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