Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm
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Published:2023-07-28
Issue:15
Volume:24
Page:12087
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Zalewski Daniel1ORCID, Chmiel Paulina1ORCID, Kołodziej Przemysław1ORCID, Borowski Grzegorz2, Feldo Marcin2, Kocki Janusz3ORCID, Bogucka-Kocka Anna1ORCID
Affiliation:
1. Chair and Department of Biology and Genetics, Medical University of Lublin, 4a Chodźki St., 20-093 Lublin, Poland 2. Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, 11 Staszica St., 20-081 Lublin, Poland 3. Department of Clinical Genetics, Chair of Medical Genetics, Medical University of Lublin, 11 Radziwiłłowska St., 20-080 Lublin, Poland
Abstract
Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed disease and is burdened with a high mortality rate (65–85%) from AAA rupture. Studies indicate that abnormal regulation of angiogenesis and inflammation contributes to progression and onset of this disease; however, dysregulations in the molecular pathways associated with this disease are not yet fully explained. Therefore, in our study, we aimed to identify dysregulations in the key regulators of angiogenesis and inflammation in patients with AAA in peripheral blood mononuclear cells (using qPCR) and plasma samples (using ELISA). Expression levels of ANGPT1, CXCL8, PDGFA, TGFB1, VEGFB, and VEGFC and plasma levels of TGF-alpha, TGF-beta 1, VEGF-A, and VEGF-C were found to be significantly altered in the AAA group compared to the control subjects without AAA. Associations between analyzed factors and risk factors or biochemical parameters were also explored. Any of the analyzed factors was associated with the size of the aneurysm. The presented study identified dysregulations in key angiogenesis- and inflammation-related factors potentially involved in AAA formation, giving new insight into the molecular pathways involved in the development of this disease and providing candidates for biomarkers that could serve as diagnostic or therapeutic targets.
Funder
Medical University of Lublin
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference75 articles.
1. Kessler, V., Klopf, J., Eilenberg, W., Neumayer, C., and Brostjan, C. (2022). AAA Revisited: A Comprehensive Review of Risk Factors, Management, and Hallmarks of Pathogenesis. Biomedicines, 10. 2. Abdominal Aortic Aneurysms;Sakalihasan;Nat. Rev. Dis. Primers,2018 3. Abdominal Aortic Aneurysms;Kent;N. Engl. J. Med.,2014 4. Li, X., Zhao, G., Zhang, J., Duan, Z., and Xin, S. (2013). Prevalence and Trends of the Abdominal Aortic Aneurysms Epidemic in General Population—A Meta-Analysis. PLoS ONE, 8. 5. Population-Based Study of Ruptured Abdominal Aortic Aneurysm;Laine;Br. J. Surg.,2016
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