Presepsin in Human Milk Is Delivery Mode and Gender Dependent-Reference-Cited by-同舟云学术

Presepsin in Human Milk Is Delivery Mode and Gender Dependent

Published:2024-08-03 Issue:15 Volume:16 Page:2554
ISSN:2072-6643
Container-title:Nutrients
language:en
Short-container-title:Nutrients

Author:

D’Adamo Ebe¹,Peila Chiara²^ORCID,Strozzi Mariachiara³,Barolo Roberta²,Maconi Antonio⁴^ORCID,Nanni Arianna¹,Botondi Valentina¹,Coscia Alessandra²,Bertino Enrico²,Gazzolo Francesca⁵,Abdelhameed Ali Saber⁶^ORCID,Conte Mariangela¹,Picone Simonetta⁷,D’Andrea Marianna¹,Lizzi Mauro¹^ORCID,Quarta Maria Teresa¹,Gazzolo Diego¹^ORCID

Affiliation:

1. Neonatal Intensive Care Unit, “G. D’Annunzio” University, 66100 Chieti, Italy

2. Neonatology Unit, Department of Public Health and Pediatrics, University of Turin, 10124 Torino, Italy

3. Department of Pediatrics and Neonatology, Cardinal Massaia Hospital, 14100 Asti, Italy

4. Department of Maternal, Fetal and Neonatal Medicine, ASO SS Antonio, Biagio and C. Arrigo, 15121 Alessandria, Italy

5. Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy

6. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

7. Neonatal Intensive Care Unit, Policlinico Casilino, 00169 Rome, Italy

Abstract

Breast milk (BM) is a unique food due to its nutritional composition and anti-inflammatory characteristics. Evidence has emerged on the role of Presepsin (PSEP) as a reliable marker of early sepsis diagnosis. In the present study, we aimed to investigate the measurability of PSEP in BM according to different maturation stages (colostrum, C; transition, Tr; and mature milks, Mt) and corrected for delivery mode and gender. We conducted a multicenter prospective case–control study in women who had delivered 22 term (T) and 22 preterm (PT) infants. A total of 44 human milk samples were collected and stored at −80 °C. BM PSEP (pg/mL) levels were measured by using a rapid chemiluminescent enzyme immunoassay. PSEP was detected in all samples analyzed. Higher (p < 0.05) BM PSEP concentrations were observed in the PT compared to the T infants. According to the grade of maturation, higher (p < 0.05) levels of PSEP in C compared to Tr and Mt milks were observed in the whole study population. The BM subtypes’ degrees of maturation were delivery mode and gender dependent. We found that PSEP at high concentrations supports its antimicrobial action both in PT and T infants. These results open the door to further studies investigating the role of PSEP.

Funder

I COLORI DELLA VITA FOUNDATION

DANONE

King Saud University

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6643/16/15/2554/pdf

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