New Sorbicillinoids from the Mangrove Endophytic Fungus Trichoderma reesei SCNU-F0042-Reference-Cited by-同舟云学术

New Sorbicillinoids from the Mangrove Endophytic Fungus Trichoderma reesei SCNU-F0042

Published:2023-08-05 Issue:8 Volume:21 Page:442
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Li Jialin¹,Chen Tao¹^ORCID,Yu Jianchen²,Jia Hao¹,Chen Chen¹,Long Yuhua¹

Affiliation:

1. GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, School of Chemistry, South China Normal University, Guangzhou 510006, China

2. Key Laboratory of Tropical Disease Control, Ministry of Education, Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China

Abstract

Three new dimeric sorbicillinoids (1–3) and one new 3,4,6-trisubstituted α-pyrone (5), along with seven analogues (4 and 6–11), were isolated from the mangrove endophytic fungus Trichoderma reesei SCNU-F0042 under the guidance of molecular networking approach. Their chemical structures were established by 1D and 2D NMR HR-ESI-MS and ECD analysis. In a bioassay, compound 2 exhibited moderate SARS-CoV-2 inhibitory activity with an EC50 value of 29.0 μM.

Funder

Guangdong Marine Economy Development Special Project

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science

Link

https://www.mdpi.com/1660-3397/21/8/442/pdf

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