Eosinophilic Cationic Protein and Immunoglobulin E: Unraveling Biomarkers in Chronic Pediatric Cough

Author:

Lazova Snezhina123ORCID,Naydenova Kremena4ORCID,Velikova Tsvetelina3ORCID

Affiliation:

1. Pediatric Clinic, University Hospital “N. I. Pirogov”, 21 “General Eduard I. Totleben” blvd, 1606 Sofia, Bulgaria

2. Department of Healthcare, Faculty of Public Health “Prof. Tsekomir Vodenicharov, MD, DSc”, Medical University of Sofia, Bialo More 8 Str., 1527 Sofia, Bulgaria

3. Medical Faculty, Sofia University St. Kliment Ohridski, 1 Kozyak Str., 1407 Sofia, Bulgaria

4. Clinical Center of Allergology, University Hospital Alexandrovska, Medical University of Sofia, Georgi Sofyiski 1 Str., 1431 Sofia, Bulgaria

Abstract

Although the cough reflex is one of the essential protective mechanisms in the respiratory tract, it is considered a considerable health problem in adults and children when it becomes chronic and hypersensitive. However, the need for biomarkers for chronic cough in children and adults is critical. The problem with cough is also a severe symptom in hypersensitivity children. Respiratory infections are a considerable challenge for pediatricians, especially in allergic children. The term cough hypersensitivity syndrome, although introduced in adults, was questioned for children. Eosinophil cationic protein (ECP) is a promising marker for chronic cough but still needs to be validated and proved in clinical settings. In this review article, we aimed to discuss the possible role of ECP in connection to IgE for chronic cough in children.

Funder

European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria

Publisher

MDPI AG

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