Overview of the Circadian Clock in the Hair Follicle Cycle

Author:

Niu Ye1,Wang Yujie1,Chen Hao1,Liu Xiaomei1,Liu Jinyu1

Affiliation:

1. Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China

Abstract

The circadian clock adapts to the light–dark cycle and autonomously generates physiological and metabolic rhythmicity. Its activity depends on the central suprachiasmatic pacemaker. However, it also has an independent function in peripheral tissues such as the liver, adipose tissue, and skin, which integrate environmental signals and energy homeostasis. Hair follicles (HFs) maintain homeostasis through the HF cycle, which depends heavily on HF stem cell self-renewal and the related metabolic reprogramming. Studies have shown that circadian clock dysregulation in HFs perturbs cell cycle progression. Moreover, there is increasing evidence that the circadian clock exerts a significant influence on glucose metabolism, feeding/fasting, stem cell differentiation, and senescence. This suggests that circadian metabolic crosstalk plays an essential role in regulating HF regeneration. An improved understanding of the role of the circadian clock in HFs may facilitate the discovery of new drug targets for hair loss. Therefore, the present review provides a discussion of the relationship between the circadian clock and HF regeneration, mainly from the perspective of HF metabolism, and summarizes the current understanding of the mechanisms by which HFs function.

Funder

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

Reference103 articles.

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