Numerical Simulation for a Hybrid Variable-Order Multi-Vaccination COVID-19 Mathematical Model

Author:

Sweilam Nasser1ORCID,Al-Mekhlafi Seham23ORCID,Salama Reem4,Assiri Tagreed5

Affiliation:

1. Department of Mathematics, Faculty of Science, Cairo University, Giza 12613, Egypt

2. Department of Mathematics, Faculty of Education, Sana’a University, Sana’a 1247, Yemen

3. Department of Engineering Mathematics and Physics, Future University in Egypt, New Cairo 11835, Egypt

4. Department of Mathematics, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt

5. Department of mathematics, Faculty of Science, Umm Al-Qura University, Makkah 21961, Saudi Arabia

Abstract

In this paper, a hybrid variable-order mathematical model for multi-vaccination COVID-19 is analyzed. The hybrid variable-order derivative is defined as a linear combination of the variable-order integral of Riemann–Liouville and the variable-order Caputo derivative. A symmetry parameter σ is presented in order to be consistent with the physical model problem. The existence, uniqueness, boundedness and positivity of the proposed model are given. Moreover, the stability of the proposed model is discussed. The theta finite difference method with the discretization of the hybrid variable-order operator is developed for solving numerically the model problem. This method can be explicit or fully implicit with a large stability region depending on values of the factor Θ. The convergence and stability analysis of the proposed method are proved. Moreover, the fourth order generalized Runge–Kutta method is also used to study the proposed model. Comparative studies and numerical examples are presented. We found that the proposed model is also more general than the model in the previous study; the results obtained by the proposed method are more stable than previous research in this area.

Publisher

MDPI AG

Subject

Physics and Astronomy (miscellaneous),General Mathematics,Chemistry (miscellaneous),Computer Science (miscellaneous)

Reference42 articles.

1. United States Food and Drug Administration (2021, June 17). FDA Takes Key Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for First COVID-19 Vaccine, Available online: https://www.fda.gov/news-events/press-announcements/fda-takes-key-action-fight-against-COVID-19-issuing-emergency-use-authorization-first-COVID-19.

2. (2021, July 14). Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Authorized in the United States, Available online: https://www.cdc.gov/vaccines/COVID-19/clinical-considerations/COVID-19-vaccines-us.html.

3. Rare and extreme events: The case of COVID-19 pandemic;Machado;Nonlinear Dyn.,2020

4. Fractional optimal control dynamics of Coronavirus model with Mittag-Leffler law;Bonyah;Ecol. Complex.,2020

5. Modeling and analysis of the dynamics of novel coronavirus (COVID-19) with Caputo fractional derivative;Ali;Results Phys.,2020

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