Author:
Wang Bin,Cheng Xiaowei,Fu Shihui,Sun Ding,Zhang Weiguang,Liu Weicen,Miao Xinyu,Luo Qing,Li Hao,Zhang Jie,Jin Xinye,Zhao Yali,Yao Yao,Chen Yizhi
Abstract
This longitudinal cohort study explored the associations of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), and β-C-terminal telopeptide of type 1 collagen (β-CTX) levels with all-cause mortality in centenarians. The study included 952 centenarians (81.4% female). During a median follow-up of 32 months, 752 (78.9%) centenarians died. The estimated 1-year, 3-year, and 5-year survival rates were 80.0%, 45.7%, and 23.6%, respectively. The association of mortality with 25(OH)D was linear, whereas the associations with PTH and β-CTX were J-shaped, with a lower risk below the median levels. Compared with 25(OH)D of ≥30 ng/mL, 25(OH)D < 30 ng/mL was associated with increased mortality (HR 1.52, 95% CI 1.24–1.86, p < 0.001). Compared with PTH of ≤65 pg/mL, PTH > 65 pg/mL was associated with increased mortality (HR 1.30, 95% CI 1.08–1.56, p = 0.005). Compared with β-CTX of <0.55 ng/mL, β-CTX ≥ 0.55 ng/mL was associated with increased mortality (HR 1.30, 95% CI 1.10–1.54, p = 0.002). A higher β-CTX level (even in the clinical reference range of 0.55–1.01 ng/mL) was associated with increased mortality (HR 1.23, 95% CI 1.04–1.47, p = 0.018). Centenarians with 25(OH)D < 30 ng/mL, PTH > 65 pg/mL, and β-CTX ≥ 0.55 ng/mL had a 2.77-fold (95% CI 1.99–3.85, p < 0.001) increased risk of mortality when compared with those with 25(OH)D of >30 ng/mL, PTH < 65 pg/mL, and β-CTX < 0.55 ng/mL. Lower serum 25(OH)D and higher PTH and β-CTX were independently correlated with increased all-cause mortality in Chinese community-dwelling centenarians.
Funder
Specialized Scientific Research Project of Military Health Care
National Natural Science Foundation of China
Specialized Scientific Program of the Innovation Platform for Academicians of Hainan Province
Hainan Provincial Natural Science Foundation of China
Academician Chen Xiangmei of Hainan Province Kidney Diseases Team Innovation Center
National Key R&D Program of China
National S&T Resource Sharing service platform Project of China
Academician Wang Fusheng Station of Hainan Province
Subject
Food Science,Nutrition and Dietetics
Cited by
2 articles.
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