Author:
Ritskes-Hoitinga Merel,van Luijk Judith
Abstract
This paper describes the introduction of the systematic review methodology in animal-based research and the added value of this methodology in relation to the 3Rs and beyond. The 3Rs refer to Replacement, Reduction, and Refinement of animal studies. A systematic review (SR) is defined as a literature review focused on a single question that tries to identify, appraise, select, and synthesise all high-quality research evidence relevant to that question. Examples are given on how SRs lead to the implementation of the 3Rs and better science. Additionally, a broader context is given regarding societal, political, and scientific developments. Various examples of systematic reviews are given to illustrate the current situation regarding reporting, quality, and translatability of animal-based research. Furthermore, initiatives that have emerged to move further towards more responsible and sustainable research is of benefit for both animals and humans.
Subject
General Veterinary,Animal Science and Zoology
Reference36 articles.
1. The Principles of Humane Experimental Technique;Russell,1959
2. Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity
3. Nutrition and Animal Welfare;Ritskes-Hoitinga,2004
4. Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies;Hart,1995
5. The Next Steps Towards Responsible Animal-Based Research;Van Luijk,2017
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