Recent Advances of Chitosan-Based Hydrogels for Skin-Wound Dressings
Author:
Guo Wei1, Ding Xiaoyue1, Zhang Han1, Liu Zhenzhong2ORCID, Han Yanting1, Wei Qianqian13, Okoro Oseweuba Valentine3ORCID, Shavandi Amin3ORCID, Nie Lei1ORCID
Affiliation:
1. College of Life Sciences, Xinyang Normal University, Xinyang 464000, China 2. Taizhou Key Laboratory of Medical Devices and Advanced Materials, Taizhou Institute of Zhejiang University, Taizhou 318000, China 3. 3BIO-BioMatter, École Polytechnique de Bruxelles, Université Libre de Bruxelles (ULB), Avenue F.D. Roosevelt, 50-CP 165/61, 1050 Brussels, Belgium
Abstract
The management of wound healing represents a significant clinical challenge due to the complicated processes involved. Chitosan has remarkable properties that effectively prevent certain microorganisms from entering the body and positively influence both red blood cell aggregation and platelet adhesion and aggregation in the bloodstream, resulting in a favorable hemostatic outcome. In recent years, chitosan-based hydrogels have been widely used as wound dressings due to their biodegradability, biocompatibility, safety, non-toxicity, bioadhesiveness, and soft texture resembling the extracellular matrix. This article first summarizes an overview of the main chemical modifications of chitosan for wound dressings and then reviews the desired properties of chitosan-based hydrogel dressings. The applications of chitosan-based hydrogels in wound healing, including burn wounds, surgical wounds, infected wounds, and diabetic wounds are then discussed. Finally, future prospects for chitosan-based hydrogels as wound dressings are discussed. It is anticipated that this review will form a basis for the development of a range of chitosan-based hydrogel dressings for clinical treatment.
Funder
Taizhou Special Support Plan for High-level Talents Key Scientific Research Projects of Higher Education Institutions in Henan Province Taizhou Science and Technology Plan Project
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