An In Vitro Pilot Study Investigating the Antineoplastic Effects of GP-2250 on Cutaneous Squamous Cell Carcinoma Cell Lines: Preliminary Results-Reference-Cited by-同舟云学术

An In Vitro Pilot Study Investigating the Antineoplastic Effects of GP-2250 on Cutaneous Squamous Cell Carcinoma Cell Lines: Preliminary Results

Published:2023-03-14 Issue:1 Volume:3 Page:85-96
ISSN:2673-6179
Container-title:Dermato
language:en
Short-container-title:Dermato

Author:

Barras Milan¹,Schmitz Lutz¹^ORCID,Braumann Chris²,Uhl Waldemar²^ORCID,Skrygan Marina¹,Buchholz Marie²,Meyer Thomas¹^ORCID,Stockfleth Eggert¹,Müller Thomas³,Becker Jürgen C.⁴⁵^ORCID,Gambichler Thilo¹^ORCID

Affiliation:

1. Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany

2. Department of General and Visceral Surgery, St. Josef-Hospital, Ruhr-University Bochum, 44791 Bochum, Germany

3. Geistlich Pharma AG, 6110 Wolhusen, Switzerland

4. Department of Translational Skin Cancer Research, Dermatology, University Hospital Essen, 45147 Essen, Germany

5. German Cancer Consortium (DKTK), Partner Site Essen and the German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany

Abstract

Advanced cutaneous squamous cell carcinoma (cSCC) can be a life-threatening disease for which effective and safe treatment in advanced stages is very limited. GP-2250 has been recently proven to have—in vitro and in vivo—antineoplastic effects on cancer cells. This study aims to investigate the potential anti-neoplastic effects of GP-2250 on the cSCC cell lines SCC13 and A431 through dose finding assessments, MTT cytotoxicity assays, cell migration assays, BrdU proliferation assays and FCM analysis. Our preliminary results have shown for the first time evidence for anti-neoplastic effects of GP-2250 on cSCC cells, enhancing cytotoxicity, attenuating cancer cell proliferation, inducing apoptosis and reducing tumour cell migration. Further investigations evaluating the modes of action of GP-2250 on cSCC cell lines are warranted in order to justify the use in vivo studies.

Publisher

MDPI AG

Link

https://www.mdpi.com/2673-6179/3/1/7/pdf

Reference39 articles.

1. Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease;Burton;Am. J. Clin. Dermatol.,2016

2. Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline;Stratigos;Eur. J. Cancer,2015

3. Incidence, Mortality, and Trends of Nonmelanoma Skin Cancer in Germany;Leiter;J. Investig. Dermatol.,2017

4. Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the US Population, 2012;Rogers;JAMA Dermatol.,2015

5. Incidence trends of nonmelanoma skin cancer in Germany from 1998 to 2010;Rudolph;JDDG J. Dtsch. Dermatol. Ges.,2015

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The effect of GP-2250 on cultured virus-negative Merkel cell carcinoma cells: preliminary results;Journal of Cancer Research and Clinical Oncology;2023-06-14