Frugal and Translatable [15O]O2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR-Reference-Cited by-同舟云学术

Frugal and Translatable [15O]O2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR

Published:2024-04-25 Issue:9 Volume:14 Page:902
ISSN:2075-4418
Container-title:Diagnostics
language:en
Short-container-title:Diagnostics

Author:

Corsaut Jeffrey¹²,Soto Elmer¹²,Biernaski Heather¹²,Kovacs Michael S.¹²³⁴,St. Lawrence Keith¹²⁴,Hicks Justin W.¹²⁴^ORCID

Affiliation:

1. Lawson Health Research Institute, London, ON N6A 5W9, Canada

2. Saint Joseph’s Health Canada London, London, ON N6A 4V2, Canada

3. Department of Medical Imaging, Western University, London, ON N6A 3K7, Canada

4. Department of Medical Biophysics, Western University, London, ON N6A 3K7, Canada

Abstract

Oxygen-15 (β+, t1/2 = 122 s) radiolabeled diatomic oxygen, in conjunction with positron emission tomography, is the gold standard to quantitatively measure the metabolic rate of oxygen consumption in the living human brain. We present herein a protocol for safe and effective delivery of [15O]O2 over 200 m to a human subject for inhalation. A frugal quality control testing procedure was devised and validated. This protocol can act as a blueprint for other sites seeking to implement similar imaging programs.

Funder

Canadian Institute for Health Research Project grant

Publisher

MDPI AG

Link

https://www.mdpi.com/2075-4418/14/9/902/pdf

Reference13 articles.

1. Oxygen metabolism, oxygen extraction and positron emission tomography: Historical perspective and impact on basic and clinical neuroscience;Baron;NeuroImage,2012

2. Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI;Fan;NeuroImage,2020

3. Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography;Mintun;J. Nucl. Med.,1984

4. Integrated PET/MRI scanner with oxygen-15 labeled gases for quantification of cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen;Ito;Ann. Nucl. Med.,2021

5. Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner;Su;J. Cereb. Blood Flow Metab.,2017