Sexual Dimorphisms and Asymmetries of the Thalamo-Cortical Pathways and Subcortical Grey Matter of Term Born Healthy Neonates: An Investigation with Diffusion Tensor MRI

Abstract

Diffusion-tensor-MRI was performed on 28 term born neonates. For each hemisphere, we quantified separately the axial and the radial diffusion (AD, RD), the apparent diffusion coefficient (ADC) and the fractional anisotropy (FA) of the thalamo-cortical pathway (THC) and four structures: thalamus (TH), putamen (PT), caudate nucleus (CN) and globus-pallidus (GP). There was no significant difference between boys and girls in either the left or in the right hemispheric THC, TH, GP, CN and PT. In the combined group (boys + girls) significant left greater than right symmetry was observed in the THC (AD, RD and ADC), and TH (AD, ADC). Within the same group, we reported left greater than right asymmetry in the PT (FA), CN (RD and ADC). Different findings were recorded when we split the group of neonates by gender. Girls exhibited right > left AD, RD and ADC in the THC and left > right FA in the PT. In the group of boys, we observed right > left RD and ADC. We also reported left > right FA in the PT and left > right RD in the CN. These results provide insights into normal asymmetric development of sensory-motor networks within boys and girls.