Neuroendocrine Breast Carcinoma: Interesting Images of an Underdiagnosed Entity

Author:

Kosmidis Christoforos1,Boulogeorgou Kassiani2ORCID,Roulia Panagiota1ORCID,Dagher Marios1,Anthimidis Georgios3,Petrakis Georgios2ORCID,Koulouris Charilaos1,Mantalovas Stylianos1ORCID,Laskou Styliani1ORCID,Magra Vasiliki1ORCID,Karakousis Vasileios Alexandros1ORCID,Sevva Christina1ORCID,Paschou Eleni1ORCID,Stergios Vasileios1,Kosmidis Stylianos4ORCID,Mystakidou Chrysi Maria5ORCID,Theodorou Vasiliki5,Katsios Nikolaos Iason6ORCID,Koletsa Triantafyllia2,Sapalidis Konstantinos1ORCID,Kesisoglou Isaak1

Affiliation:

1. 3rd Surgical Department, University General Hospital of Thessaloniki “AHEPA”, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece

2. Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece

3. European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece

4. Department of Medicine, Medical University of Plovdiv, y.B.Apo15A, 4002 Plovdiv, Bulgaria

5. Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

6. Faculty of Health Sciences, Medical School, University of Ioannina, 45110 Ioannina, Greece

Abstract

Breast cancer is the most common type of cancer of the female gender. A rare subtype of breast cancer is the invasive breast carcinoma (IBC) with neuroendocrine (NE) differentiation. Its incident is believed to be 0.1% to 5% of all breast cancers. We report a rare case of a 66-year old woman who presented with an isolated nodule of the left breast. The patient underwent modified radical mastectomy. Pathology revealed invasive breast carcinoma with neuroendocrine differentiation. Invasive breast carcinoma is an extremely rare group of neoplasms, the exact frequency of which cannot be determined with current data. Therefore, it is necessary for future studies to focus on the pathophysiology of this subtype of breast cancer and on the potential therapeutic approaches.

Publisher

MDPI AG

Reference10 articles.

1. Primary Neuroendocrine Neoplasms of the Breast: Still Open Issues;Gallo;Front. Endocrinol.,2021

2. Neuroendocrine Tumors of the Breast;Rosen;Arch. Pathol. Lab. Med.,2017

3. Breast cancer with neuroendocrine differentiation: An update based on the latest WHO classification;Tsang;Mod. Pathol.,2021

4. WHO Classification of Tumors Series (2019). Breast Tumors.

5. Neuroendocrine Differentiated Breast Cancer Cases: A Retrospective Analysis and Literature Review;Ozdemir;Med. Bull. Sisli Etfal Hosp.,2021

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