EML4-ALK Gene Mutation Detected with New NGS Lung Cancer Panel CDx Using Sputum Cytology in a Case of Advanced NSCLC-Reference-Cited by-同舟云学术

EML4-ALK Gene Mutation Detected with New NGS Lung Cancer Panel CDx Using Sputum Cytology in a Case of Advanced NSCLC

Published:2023-07-10 Issue:14 Volume:13 Page:2327
ISSN:2075-4418
Container-title:Diagnostics
language:en
Short-container-title:Diagnostics

Author:

Morikawa Kei¹^ORCID,Kinoshita Kohei¹,Matsuzawa Shin¹,Kida Hirotaka¹,Handa Hiroshi¹,Inoue Takeo¹,Nakamura Seiji²,Sato Yoshiharu²,Mineshita Masamichi¹

Affiliation:

1. Division of Respiratory Diseases, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan

2. DNA Chip Research Inc., Tokyo 105-0022, Japan

Abstract

The detection of driver gene mutations has become essential for lung cancer; however, insufficient sample sizes make gene panel tests difficult to use. We previously reported that the lung cancer compact panel TM (LCCP) could detect EGFR and MET gene mutations with sputum cytology. To date, the detection of gene mutation using RNA from sputum samples is considered practically difficult. We report a case in which the EML4-ALK fusion gene was successfully detected from a sputum sample using the LCCP that was just released in Japan as a new next-generation sequencing lung cancer panel, CDx.

Publisher

MDPI AG

Subject

Clinical Biochemistry

Link

https://www.mdpi.com/2075-4418/13/14/2327/pdf

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