Alterations in Macular Microvasculature in Pterygium Patients Measured by OCT Angiography
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Published:2023-04-30
Issue:9
Volume:13
Page:1603
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ISSN:2075-4418
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Container-title:Diagnostics
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language:en
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Short-container-title:Diagnostics
Author:
Cai Yingjun12, Wu Zhenkai3, Yuan Ruolan12, Wang Pingbao12, Xu Huizhuo12, Xu Yi12, Yao Xueyan12, Wang Hua12, Zou Jing12ORCID
Affiliation:
1. Eye Center of Xiangya Hospital, Hunan Key Laboratory of Ophthalmology, Central South University, Changsha 410008, China 2. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China 3. The First People’s Hospital of Changde, Changde 415000, China
Abstract
Previous studies have reported an association between pterygia and maculopathy, yet the underlying mechanisms and alterations to the macular microvasculature in pterygium patients have yet to be fully elucidated. Our study conducted an analysis of macular superficial vessel length density (VLD) and vessel perfusion density (VPD) to establish associations between the conjunctival and macular microvasculature in patients with unilateral and bilateral pterygia. We revealed a loss of macular microvasculature in the outer nasal (ON) region in both unilateral and bilateral pterygium patients. VLD was significantly decreased in both pterygium groups in the ON region, and VPD was notably lower in bilateral pterygium patients in the same area. Furthermore, in unilateral pterygium patients, the vessel percent pixel coverage (PPC) of the pterygium and the area of the pterygium exhibited a negative correlation with VLD in the ON region. Multiple stepwise linear regression models indicated that the PPC could best predict VLP in the ON region. Taken together, our findings suggest that patients with pterygia may be more susceptible to macular diseases, and this may be due to a compensatory increase in blood perfusion via the anterior ciliary artery. These results underscore the importance of managing maculopathy in patients with pterygia.
Funder
National Natural Science Foundation of China Natural Science Found of Hunan Province central committee guides’ local science and technology development special project by the Ministry of Science and Technology Major Special Project of Key Research and Development Program of Ningxia Province
Subject
Clinical Biochemistry
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