Preliminary Investigation into the Prevalence of G6PD Deficiency in a Pediatric African American Population Using a Near-Patient Diagnostic Platform

Author:

Leung-Pineda Van1ORCID,Weinzierl Elizabeth P.1,Rogers Beverly B.1

Affiliation:

1. Department of Pathology and Laboratory Medicine, Children’s Healthcare of Atlanta, and Emory University School of Medicine, Atlanta, GA 30322, USA

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in the African American population. We identified eighteen G6PD-deficient samples (9%) in a study of residual, de-identified whole blood specimens from 200 African American pediatric patients using a point-of-care instrument. This highlights the possibility of a rapid time to result for G6PD testing, which can be valuable in some clinical scenarios.

Funder

Baebies, Inc.

Publisher

MDPI AG

Subject

Clinical Biochemistry

Reference22 articles.

1. Thirty-five males with severe (Class 1) G6PD deficiency (c.637G>T) in a North American family of European ancestry;Bahr;Blood Cells Mol. Dis.,2021

2. Glader, B. (2023, October 24). Diagnosis and Management of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency. UpToDate. Available online: https://www.uptodate.com/contents/diagnosis-and-management-of-glucose-6-phosphate-dehydrogenase-g6pd-deficiency.

3. Medications and glucose-6-phosphate dehydrogenase deficiency: An evidence-based review;Youngster;Drug Saf.,2010

4. Hemolytic crisis in a G6PD-deficient infant after ingestion of pumpkin;Zuccotti;Ital. J. Pediatr.,2014

5. Clinical characteristics of G6PD deficiency in infants with marked hyperbilirubinemia;Weng;J. Pediatr. Hematol. Oncol.,2010

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