Conserved Sequence Analysis of Influenza A Virus HA Segment and Its Application in Rapid Typing

Author:

Lin Qianyu,Ji Xiang,Wu FengORCID,Ma LanORCID

Abstract

The high mutation rate of the influenza A virus hemagglutinin segment poses great challenges to its long-term effective testing and subtyping. Our conserved sequence searching method achieves high-specificity conserved sequences on H1–H9 subtypes. In addition, PCR experiments show that primers based on conserved sequences can be used in influenza A virus HA subtyping. Conserved sequence-based primers are expected to be long-term, effective subtyping tools for influenza A virus HA.

Funder

National Key R & D Plan in China

Publisher

MDPI AG

Subject

Clinical Biochemistry

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