Tubular Structure Segmentation via Multi-Scale Reverse Attention Sparse Convolution

Author:

Zeng Xueqiang12,Guo Yingwei23ORCID,Zaman Asim24ORCID,Hassan Haseeb2,Lu Jiaxi12,Xu Jiaxuan5,Yang Huihui12,Miao Xiaoqiang23,Cao Anbo12,Yang Yingjian23ORCID,Chen Rongchang678,Kang Yan1239ORCID

Affiliation:

1. School of Applied Technology, Shenzhen University, Shenzhen 518060, China

2. College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China

3. College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, China

4. School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen 518060, China

5. State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China

6. Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, Shenzhen 518001, China

7. The Second Clinical Medical College, Jinan University, Guangzhou 518001, China

8. The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518001, China

9. Engineering Research Centre of Medical Imaging and Intelligent Analysis, Ministry of Education, Shenyang 110169, China

Abstract

Cerebrovascular and airway structures are tubular structures used for transporting blood and gases, respectively, providing essential support for the normal activities of the human body. Accurately segmenting these tubular structures is the basis of morphology research and pathological detection. Nevertheless, accurately segmenting these structures from images presents great challenges due to their complex morphological and topological characteristics. To address this challenge, this paper proposes a framework UARAI based on the U-Net multi-scale reverse attention network and sparse convolution network. The framework utilizes a multi-scale structure to effectively extract the global and deep detail features of vessels and airways. Further, it enhances the extraction ability of fine-edged features by a joint reverse attention module. In addition, the sparse convolution structure is introduced to improve the features’ expression ability without increasing the model’s complexity. Finally, the proposed training sample cropping strategy reduces the influence of block boundaries on the accuracy of tubular structure segmentation. The experimental findings demonstrate that the UARAI-based metrics, namely Dice and IoU, achieve impressive scores of 90.31% and 82.33% for cerebrovascular segmentation and 93.34% and 87.51% for airway segmentation, respectively. Compared to commonly employed segmentation techniques, the proposed method exhibits remarkable accuracy and robustness in delineating tubular structures such as cerebrovascular and airway structures. These results hold significant promise in facilitating medical image analysis and clinical diagnosis, offering invaluable support to healthcare professionals.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

special program for key fields of colleges and universities in Guangdong Province (biomedicine and health) of China

Stable Support Plan for Colleges and Universities in Shenzhen of China

Publisher

MDPI AG

Subject

Clinical Biochemistry

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