Evaluation of Crohn’s Disease Small-Bowel Mucosal Healing Using Capsule Endoscopy and Usefulness of Leucine-Rich α2-Glycoprotein

Author:

Hiraga Hiroto1,Chinda Daisuke2ORCID,Hasui Keisuke1,Murai Yasuhisa1ORCID,Maeda Takato1,Higuchi Naoki1ORCID,Ogasawara Kohei1,Kudo Sae1,Sawada Yohei1,Tatsuta Tetsuya1,Kikuchi Hidezumi1,Ebina Mami2,Hiraga Noriko1,Mikami Tatsuya3ORCID,Sakuraba Hirotake1,Fukuda Shinsaku1

Affiliation:

1. Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan

2. Division of Endoscopy, Hirosaki University Hospital, Hirosaki 036-8563, Japan

3. Center of Healthy Aging Innovation, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan

Abstract

Recently, the importance of achieving clinical and deep remissions with mucosal healing (MH) has been demonstrated as a therapeutic goal to avoid Crohn’s disease (CD) surgical operations. Although ileocolonoscopy (CS) is considered the gold standard, there are increasing reports on the benefits of capsule endoscopy (CE) and serum leucine-rich α2-glycoprotein (LRG) for evaluating small-bowel lesions in CD. We evaluated the data of 20 patients with CD who underwent CE in our department between July 2020 and June 2021 and whose serum LRG level was measured within 2 months. Concerning the mean LRG value, there was no significant difference between the CS-MH and CS-non-MH groups. Conversely, the mean LRG level was 10.0 μg/mL in seven patients in the CE-MH group and 15.2 μg/mL in 11 patients in the CE-non-MH group with a significant difference between the two groups (p = 0.0025). This study’s findings show that CE can sufficiently determine total MH in most cases, and LRG is useful for evaluating CD small-bowel MH because of its correlation with CE-MH. Furthermore, satisfying CS-MH criteria and a cut-off value of 13.4 μg/mL for LRG suggests its usefulness as a CD small-bowel MH marker, which could be incorporated into the treat-to-target strategy.

Funder

Karoji Memorial Fund for Medical Research

Publisher

MDPI AG

Subject

Clinical Biochemistry

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