Sentinel Lymph Node Biopsy in Prostate Cancer: An Overview of Diagnostic Performance, Oncological Outcomes, Safety, and Feasibility

Author:

Rossin Giulio1,Zorzi Federico1ORCID,De Pablos-Rodríguez Pedro2ORCID,Biasatti Arianna1,Marenco Josè2,Ongaro Luca1ORCID,Perotti Alessandro3,Tulone Gabriele4ORCID,Traunero Fabio1ORCID,Piasentin Andrea1ORCID,Gomez-Ferrer Alvaro2,Zucchi Alessandro3ORCID,Trombetta Carlo1ORCID,Simonato Alchiede4ORCID,Rubio-Briones José5,Bartoletti Riccardo3,Ramírez-Backhaus Miguel2,Claps Francesco12ORCID

Affiliation:

1. Urological Clinic, Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada di Fiume, 447, 34149 Trieste, Italy

2. Department of Urology, Valencian Oncology Institute Foundation, FIVO, 46009 Valencia, Spain

3. Department of Translational Research and New Technologies, University of Pisa, 56126 Pisa, Italy

4. Urology Clinic, Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, 90133 Palermo, Italy

5. Clínica de Urología, Hospital VITHAS 9 de Octubre, 46015 Valencia, Spain

Abstract

Sentinel node biopsy (SNB) for prostate cancer (PCa) represents an innovative technique aimed at improving nodal staging accuracy. The routinary adoption of this procedure in patients undergoing radical prostatectomy (RP) might be crucial to identify candidates who could effectively benefit from extensive pelvic lymph nodal dissection (ePLND). Despite some promising results, SNB for PCa is still considered experimental due to the lack of solid evidence and procedural standardization. In this regard, our narrative review aimed to analyze the most recent literature in this field, providing an overview of both the diagnostic accuracy measures and the oncological outcomes of SNB.

Publisher

MDPI AG

Subject

Clinical Biochemistry

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