Low-Risk Women with Suspicious Microcalcifications in Mammography—Can an Additional Breast MRI Reduce the Biopsy Rate?

Author:

Pöschke Patrik1,Wenkel Evelyn23,Hack Carolin C.1,Beckmann Matthias W.1,Uder Michael4,Ohlmeyer Sabine4ORCID

Affiliation:

1. Department of Gynecology and Obstetrics, University Hospital Erlangen, Universitätsstraße 21-23, 91054 Erlangen, Germany

2. Radiologie München, Burgstraße 7, 80331 München, Germany

3. Medizinische Fakultät, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany

4. Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany

Abstract

Background: In the German Mammography Screening Program, 62% of ductal carcinoma in situ (DCIS) and 38% of invasive breast cancers are associated with microcalcifications (MCs). Vacuum-assisted stereotactic breast biopsies are necessary to distinguish precancerous lesions from benign calcifications because mammographic discrimination is not possible. The aim of this study was to investigate if breast magnetic resonance imaging (MRM) could assist the evaluation of MCs and thus help reduce biopsy rates. Methods: In this IRB-approved study, 58 women (mean age 58 +/− 24 years) with 59 suspicious MC clusters in the MG were eligible for this prospective single-center trial. Additional breast magnetic resonance imaging (MRI) was conducted before biopsy. Results: The breast MRI showed a sensitivity of 86%, a specificity of 84%, a positive predictive value (PPV) of 75% and a negative predictive value (NPV) of 91% for the differentiation between benign and malignant in these 59 MCs found with MG. Breast MRI in addition to MG could increase the PPV from 36% to 75% compared to MG alone. The MRI examination led to nine additional suspicious classified lesions in the study cohort. A total of 55% (5/9) of them turned out to be malignant. A total of 32 of 59 (54 %) women with suspicious MCs and benign histology were classified as non-suspicious by MRI. Conclusion: An additionally performed breast MRI could have increased the diagnostic reliability in the assessment of MCs. Further, in our small cohort, a considerable number of malignant lesions without mammographically visible MCs were revealed.

Funder

Deutsche Forschungsgemeinschaft

Friedrich-Alexander-Universität Erlangen-Nürnberg

Publisher

MDPI AG

Subject

Clinical Biochemistry

Reference38 articles.

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2. Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement;Siu;Ann. Intern. Med.,2016

3. MR Imaging for Diagnosis of Malignancy in Mammographic Microcalcifications: A Systematic Review and Meta-Analysis;Baltzer;Radiology,2017

4. Breast microcalcifications as type descriptors to stratify risk of malignancy: A systematic review and meta-analysis of 10665 cases with special focus on round/punctate microcalcifications;Rominger;Rofo,2012

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