Integrating Artificial Intelligence Tools in the Clinical Research Setting: The Ovarian Cancer Use Case

Author:

Escudero Sanchez Lorena123ORCID,Buddenkotte Thomas1456ORCID,Al Sa’d Mohammad37,McCague Cathal128ORCID,Darcy James39,Rundo Leonardo1210ORCID,Samoshkin Alex11ORCID,Graves Martin J.18ORCID,Hollamby Victoria12ORCID,Browne Paul13,Crispin-Ortuzar Mireia214,Woitek Ramona1215ORCID,Sala Evis12381617ORCID,Schönlieb Carola-Bibiane4,Doran Simon J.39ORCID,Öktem Ozan18

Affiliation:

1. Department of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK

2. Cancer Research UK Cambridge Centre, Li Ka Shing Centre, Cambridge CB2 0RE, UK

3. National Cancer Imaging Translational Accelerator (NCITA) Consortium, UK

4. Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK

5. Department for Diagnostic and Interventional Radiology and Nuclear Medicine, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany

6. Jung Diagnostics GmbH, 22335 Hamburg, Germany

7. Cancer Imaging Centre, Department of Surgery & Cancer, Imperial College, London SW7 2AZ, UK

8. Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK

9. Division of Radiotherapy and Imaging, Institute of Cancer Research, London SW7 3RP, UK

10. Department of Information and Electrical Engineering and Applied Mathematics (DIEM), University of Salerno, 84084 Fisciano, Italy

11. Office for Translational Research, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK

12. Research and Information Governance, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK

13. High Performance Computing Department, University of Cambridge, Cambridge CB3 0RB, UK

14. Department of Oncology, University of Cambridge, Cambridge CB2 0XZ, UK

15. Research Centre for Medical Image Analysis and Artificial Intelligence (MIAAI), Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, 3500 Krems, Austria

16. Dipartimento di Scienze Radiologiche ed Ematologiche, Universita Cattolica del Sacro Cuore, 00168 Rome, Italy

17. Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy

18. Department of Mathematics, KTH-Royal Institute of Technology, SE-100 44 Stockholm, Sweden

Abstract

Artificial intelligence (AI) methods applied to healthcare problems have shown enormous potential to alleviate the burden of health services worldwide and to improve the accuracy and reproducibility of predictions. In particular, developments in computer vision are creating a paradigm shift in the analysis of radiological images, where AI tools are already capable of automatically detecting and precisely delineating tumours. However, such tools are generally developed in technical departments that continue to be siloed from where the real benefit would be achieved with their usage. Significant effort still needs to be made to make these advancements available, first in academic clinical research and ultimately in the clinical setting. In this paper, we demonstrate a prototype pipeline based entirely on open-source software and free of cost to bridge this gap, simplifying the integration of tools and models developed within the AI community into the clinical research setting, ensuring an accessible platform with visualisation applications that allow end-users such as radiologists to view and interact with the outcome of these AI tools.

Funder

the EPSRC IAA grant

the CRUK National Cancer Imaging Translational Accelerator

Wellcome Trust Innovator Award, UK

The Mark Foundation for Cancer Research and Cancer Research UK (CRUK) Cambridge Centre

the National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre

the NIHR Invention for Innovation (i4i) award

Publisher

MDPI AG

Subject

Clinical Biochemistry

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