A Pilot Comparative Study between Creatinine- and Cystatin-C-Based Equations to Estimate GFR and Kidney Ultrasound Percentiles in Children with Congenital Anomalies of the Kidney and Urinary Tract-Reference-Cited by-同舟云学术

A Pilot Comparative Study between Creatinine- and Cystatin-C-Based Equations to Estimate GFR and Kidney Ultrasound Percentiles in Children with Congenital Anomalies of the Kidney and Urinary Tract

Published:2024-05-10 Issue:10 Volume:14 Page:994
ISSN:2075-4418
Container-title:Diagnostics
language:en
Short-container-title:Diagnostics

Author:

Steflea Ruxandra Maria¹²,Stroescu Ramona¹²,Gafencu Mihai¹²^ORCID,Stoicescu Emil Robert³⁴⁵^ORCID,Isac Raluca¹²^ORCID,Olariu Ioana-Cristina¹²^ORCID,Micsescu-Olah Andrada Mara¹²^ORCID,Susa Septimiu Radu⁶,Murariu Mircea²⁶,Doros Gabriela¹²

Affiliation:

1. Department of Pediatrics, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania

2. “Louis Turcanu” Emergency Hospital for Children, Iosif Nemoianu Street 2, 300011 Timisoara, Romania

3. Department of Radiology and Medical Imaging, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania

4. Research Center for Pharmaco-Toxicological Evaluations, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania

5. Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, “Politehnica” University, Mihai Viteazu Boulevard No. 1, 300222 Timisoara, Romania

6. Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania

Abstract

Congenital anomalies affecting the kidneys present significant challenges in pediatric nephrology, needing precise methods for assessing renal function and guiding therapeutic intervention. Bedside Schwartz formula with the cystatin-C-based Full Age Spectrum formula and Chronic Kidney Disease in Children (CKiD) U 25 formula used in estimating glomerular filtration rate (eGFR) and also to assess if the eGFR in association with kidney length percentiles can be a monitoring parameter for the progression of chronic kidney disease in children with congenital anomalies of the kidney and urinary tract (CAKUT). A total of 64 pediatric patients (median age at diagnostic was 12 months with an interquartile range of 2 to 60) were diagnosed with congenital anomalies in the kidney and urinary tract between June 2018 and May 2023 at “Louis Turcanu” Emergency Hospital for Children in Timisoara, Romania. Baseline characteristics, CAKUT types, associated pathologies, CKD staging, and eGFR using creatinine and cystatin C were analyzed. The mean age at the moment of examination was 116.50 months; (65, 180). Chronic kidney disease staging revealed a predominance of patients in CKD stages G1 and A1. Analysis of eGFR methods revealed a small mean difference between eGFR estimated by creatinine and cystatin C, with a moderate-strong positive correlation observed between the eGFR and ultrasound parameters. Using cystatin-C-based formulas for eGFR, in conjunction with ultrasound measurements, may offer reliable insights into renal function in pediatric patients with congenital anomalies affecting the kidney and urinary tract. However, the economic aspect must be taken into consideration because cystatin C determination is approximately eight times more expensive than that of creatinine. An interdisciplinary approach is crucial for managing patients with CAKUT.

Funder

“Victor Babes” University of Medicine and Pharmacy Timisoara

Publisher

MDPI AG

Link

https://www.mdpi.com/2075-4418/14/10/994/pdf

Reference46 articles.

1. A Primer on Congenital Anomalies of the Kidneys and Urinary Tracts (CAKUT);Murugapoopathy;Clin. J. Am. Soc. Nephrol.,2020

2. Isac, R., Basaca, D.-G., Olariu, I.-C., Stroescu, R.F., Ardelean, A.-M., Steflea, R.M., Gafencu, M., Chirita-Emandi, A., Bagiu, I.C., and Horhat, F.G. (2021). Antibiotic Resistance Patterns of Uropathogens Causing Urinary Tract Infections in Children with Congenital Anomalies of Kidney and Urinary Tract. Children, 8.

3. Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT);Rodriguez;Fetal Pediatr. Pathol.,2014

4. New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race;Inker;N. Engl. J. Med.,2021

5. New Equations to Estimate GFR in Children with CKD;Schwartz;J. Am. Soc. Nephrol.,2009