Association of Obesity with SARS-CoV-2 and Its Relationship with the Humoral Response Prior to Vaccination in the State of Mexico: A Cross-Sectional Study
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Published:2023-08-09
Issue:16
Volume:13
Page:2630
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ISSN:2075-4418
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Container-title:Diagnostics
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language:en
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Short-container-title:Diagnostics
Author:
Montes-Herrera Daniel1ORCID, Muñoz-Medina José Esteban2, Fernandes-Matano Larissa2ORCID, Salas-Lais Angel Gustavo1ORCID, Hernández-Cueto Ma. De Los Ángeles1ORCID, Santacruz-Tinoco Clara Esperanza3, Monroy-Muñoz Irma Eloisa4ORCID, Angeles-Martínez Javier1ORCID
Affiliation:
1. Central Epidemiology Laboratory, Mexican Social Security Institute, Mexico City 02990, Mexico 2. Quality of Supplies and Specialized Laboratories Coordination, Mexican Social Security Institute, Mexico City 07760, Mexico 3. Specialized Laboratories Division, Mexican Social Security Institute, Mexico City 07760, Mexico 4. Reproductive and Perinatal Health Research Department, National Institute of Perinatology, Mexico City 11000, Mexico
Abstract
Obesity is associated with an increased risk of contracting infections. This study aimed to estimate the risk of COVID-19 infection associated with obesity and to assess its role in the specific antibody response against SARS-CoV-2 in 2021. This study included 980 participants from the State of Mexico who participated in a serological survey where they were tested for SARS-CoV-2 IgG anti-S1/S2 and anti-RBD antibodies and asked for height, weight, and previous infection data via a questionnaire. Of the cohort of 980 participants, 451 (46.02%) were seropositive at the time of recruitment (45.2% symptomatic and 54.8% asymptomatic). The risk of SARS-CoV-2 infection with obesity was 2.18 (95% CI: 1.51–3.16), 2.58 (95% CI: 1.63–4.09), and 1.88 (95% CI: 1.18–2.98) for seropositive, asymptomatic, and symptomatic individuals, respectively, compared to those with normal weight. Anti-S1/S2 and anti-RBD IgG antibodies tended to be higher in overweight and obese participants in the seropositive group and stratified by different obesity classes. Additionally, there was a positive correlation between anti-S1/S2 and anti-RBD IgG antibodies and BMI in both men and women in the seropositive group. Obesity is an independent risk factor for SARS-CoV-2 infection when adjusted for confounding variables; however, the relationship between BMI and anti-S1/S2 and anti-RBD IgG antibody levels differed markedly in the presence or absence of symptoms.
Subject
Clinical Biochemistry
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