Quantitative Susceptibility Mapping: Translating an Investigative Research Tool into High Volume Clinical Diagnostic Imaging

Author:

Borzage Matthew T.,Doyle Eamon K.ORCID,Liu Chia-Shang J.ORCID,Nelson Marvin D.,Blüml StefanORCID,Wood John C.,Tamrazi BenitaORCID

Abstract

Quantitative susceptibility mapping (QSM) is an MRI-based technique for iron quantification of targeted tissue. QSM provides information relevant to clinicians in a broad range of diagnostic contexts, including sickle cell disease, inflammatory/demyelinating processes, and neoplasms. However, major MRI vendors do not offer QSM post-processing in a form ready for general use. This work describes a vendor-agnostic approach for scaling QSM analysis from a research technique to a routine diagnostic test. We provide the details needed to seamlessly integrate hardware, software, and clinical systems to provide QSM processing for a busy clinical radiology workflow. This approach can be generalized to other advanced MRI acquisitions and analyses with proven diagnostic utility, yet without crucial MR vendor support.

Funder

NIH National Cancer Institute

Publisher

MDPI AG

Subject

Clinical Biochemistry

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