A Comparative Review of Key Isothiocyanates and Their Health Benefits

Author:

Olayanju Julia B.12ORCID,Bozic Dragica3ORCID,Naidoo Uma45ORCID,Sadik Omowunmi A.6

Affiliation:

1. Department of Biology, Saint Elizabeth University, Morristown, NJ 07960, USA

2. FoodNiche Institute, Mount Olive, NJ 07828, USA

3. Department of Toxicology, School of Pharmacy, University of Belgrade, 11221 Belgrad, Serbia

4. Harvard Medical School, Boston, MA 02115, USA

5. Massachusetts General Hospital, Boston, MA 02114, USA

6. Department of Chemistry, New Jersey Institute of Technology, Newark, NJ 07102, USA

Abstract

Isothiocyanates are biologically active products resulting from the hydrolysis of glucosinolates predominantly present in cruciferous vegetables belonging to the Brassicaceae family. Numerous studies have demonstrated the diverse bioactivities of various isothiocyanates, encompassing anticarcinogenic, anti-inflammatory, and antioxidative properties. Nature harbors distinct isothiocyanate precursors, glucosinolates such as glucoraphanin and gluconastrin, each characterized by unique structures, physical properties, and pharmacological potentials. This comprehensive review aims to consolidate the current understanding of Moringa isothiocyanates, mainly 4-[(α-L-rhamnosyloxy) benzyl] isothiocyanate), comparing this compound with other well-studied isothiocyanates such as sulforaphane and phenyl ethyl isothiocyanates. The focus is directed toward elucidating differences and similarities in the efficacy of these compounds as agents with anticancer, anti-inflammatory, and antioxidative properties.

Funder

USDA NIFA AFRI Award

Publisher

MDPI AG

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