Affiliation:
1. Institute of Chemistry, Physical Chemistry—Complex Self-Organizing Systems, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 4, 06120 Halle (Saale), Germany
2. Toxicology—Drug & Medical Analytics, R&D, Head of Laboratory (“General Unknown Screening”), MVZ Medizinische Labore Dessau Kassel GmbH—Limbach Gruppe SE, Bauhüttenstraße 6, 06847 Dessau-Roßlau, Germany
Abstract
A new rapid iodination reagent, N1,N3,N5-tris[(2,4,6-trimethylpyridine)iodo(I)]-2,4,6-triphenyl-s-triazine trihexafluorophosphate, was synthesized in a modification of the established synthesis of 2,4,6-triiodo-3,5-dimethylphenol in the presence of bis(2,4,6-trimethylpyridine)iodo(I) hexafluorophosphate and used for the precise post-modification of mono- and trisubstituted phenyl compounds. We performed triple iodinations with our new phenyl-based compounds as a proof of principle of selected types of phenols, ß-sympatholytic agents and their spin-labeled derivatives, which can be employed in electron paramagnetic resonance (EPR) spectroscopy. The new rapid iodination reagent can be employed with high reactivity and regioselectivity.
Funder
Deutsche Forschungsgemeinschaft
Subject
Industrial and Manufacturing Engineering