Ferrous Salt-Catalyzed Oxidative Alkenylation of Indoles: Facile Access to 3-Alkylideneindolin-2-Ones

Author:

Tian Yunfei1ORCID,Zheng Luping1,Chen Ying1,Li Yufei1,Wang Mengna1,Fu Weijun1,Li Zejiang2

Affiliation:

1. Key Laboratory of Fuction-Oriented Porous Materials of Henan Province, College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang 471934, China

2. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Material Science, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding 071002, China

Abstract

The direct oxidative alkenylation of indoles is achieved by ferrous salts under mild conditions, which provides one effective strategy for the synthesis of 3-alkylideneindolin-2-one in a single step. This reaction system features simple and readily available materials, mild conditions, and easy accessibility. The control experiments also demonstrate a radical pathway was involved in the reaction. Moreover, the method performs well on the gram-scale experiment, which indicates that this method enjoys a broad prospect in synthetic chemistry.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Henan Province

Natural Science Foundation of Hebei Province

Publisher

MDPI AG

Subject

Physical and Theoretical Chemistry,Catalysis,General Environmental Science

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