A Comparative Study of the Antiviral Properties of Thermally Sprayed Coatings against Human Coronavirus HCoV-229E

Abstract

For decades, novel viral strains of respiratory tract infections have caused human pandemics and initiated widespread illnesses. The recent coronavirus disease 2019 (COVID-19) outbreak caused by the SARS-CoV-2 virus has raised an urgent need to develop novel antiviral coatings as one of the potential solutions to mitigate the transmission of viral pathogens. Titanium dioxide is considered an excellent candidate for viral disinfection under light irradiation, with the potential to be activated under visible light for indoor applications. This research assessed the antiviral performance of thermally sprayed TiO2 coatings under UVA and ambient light. We also report the antiviral performance of TiO2 composites with other oxides, such as Cu2O and Al2O3, produced by suspension plasma spray, atmospheric plasma spray, and suspension high-velocity oxygen fuel techniques. To evaluate the antiviral performance of the above coatings in a containment level-2 laboratory, a human common cold coronavirus, HCoV-229E, was initially used as a relevant surrogate for SARS-CoV-2. Coatings were also analyzed using SEM and XRD and were classified based on their surface roughness, porosity, and phase composition. Collectively, the thermally sprayed coatings showed comparable or slightly better antiviral activity compared to copper. The most significant level of activity observed was approximately 20% to 50% higher than that of a pure copper plate.