Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
-
Published:2023-12-19
Issue:1
Volume:16
Page:2
-
ISSN:2072-6643
-
Container-title:Nutrients
-
language:en
-
Short-container-title:Nutrients
Author:
Konstantinou Evangelia K.1, Panagiotopoulos Athanasios A.1ORCID, Argyri Konstantina1, Panoutsopoulos George I.1, Dimitriou Maria1, Gioxari Aristea1ORCID
Affiliation:
1. Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, Greece
Abstract
Breast cancer is the most frequent type of cancer in women. Oncogenic transcription factors promote the overproduction of cellular adhesion molecules and inflammatory cytokines during cancer development. Cancer cells exhibit significant upregulation of antiapoptotic proteins, resulting in increased cell survival, tumor growth, and metastasis. Research on the cell cycle-mediated apoptosis pathway for drug discovery and therapy has shown promising results. In fact, dietary phytoconstituents have been extensively researched for anticancer activity, providing indirect protection by activating endogenous defense systems. The role of polyphenols in key cancer signaling pathways could shed light on the underlying mechanisms of action. For instance, Rosmarinic Acid, a polyphenol constituent of many culinary herbs, has shown potent chemoprotective properties. In this review, we present recent progress in the investigation of natural products as potent anticancer agents, with a focus on the effect of Rosmarinic Acid on triple-negative BC cell lines resistant to hormone therapy. We highlight a variety of integrated chemical biology approaches aimed at utilizing relevant mechanisms of action that could lead to significant clinical advances in BC treatment.
Subject
Food Science,Nutrition and Dietetics
Reference106 articles.
1. Breast Cancer: Risk Assessment, Screening, and Primary Prevention;Michaels;Med. Clin. N. Am.,2023 2. Polygenic risk scores and breast cancer risk prediction;Roberts;Breast,2023 3. Petrova, M., Dimitrova, L., Dimitrova, M., Denev, P., Teneva, D., Georgieva, A., Petkova-Kirova, P., Lazarova, M., and Tasheva, K. (2023). Antitumor and Antioxidant Activities of In Vitro Cultivated and Wild-Growing Clinopodium vulgare L. Plants. Plants, 12. 4. Meirelles, L.E.F., Souza, M.V.F., Carobeli, L.R., Morelli, F., Mari, N.L., Damke, E., Shinobu Mesquita, C.S., Teixeira, J.J.V., Consolaro, M.E.L., and Silva, V. (2023). Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy. Biomedicines, 11. 5. Mediterranean diet and risk of breast cancer: An umbrella review;Toledo;Clin. Nutr.,2023
|
|