Patent Foramen Ovale and Cryptogenic Stroke: Integrated Management

Author:

Lucà Fabiana1ORCID,Pino Paolo G.2,Parrini Iris3ORCID,Di Fusco Stefania Angela4ORCID,Ceravolo Roberto5,Madeo Andrea6,Leone Angelo7,La Mair Mark8ORCID,Benedetto Francesco Antonio1,Riccio Carmine9,Oliva Fabrizio10,Colivicchi Furio4ORCID,Gulizia Michele Massimo11,Gelsomino Sandro12ORCID

Affiliation:

1. Cardiology Department, Grande Ospedale Metropolitano, GOM, AO Bianchi Melacrino Morelli, 89129 Reggio di Calabria, Italy

2. Cardiology Department, San Camillo Forlanini Hospital, 00152 Rome, Italy

3. Cardiology Department, Mauriziano Hospital, 10128 Torino, Italy

4. Clinical and Rehabilitation Cardiology Department, San Filippo Neri Hospital, ASL Roma 1, 00135 Roma, Italy

5. Cardiology Unit, Giovanni Paolo II Hospital, 88046 Lamezia, Italy

6. Ferrari Hospital, 87012 Castrovillari, Italy

7. Ospedale Santissima Annunziata, 87100 Cosenza, Italy

8. Cardiothoracic Department, Brussels University Hospital, 1090 Jette, Belgium

9. Division of Clinical Cardiology, A.O.R.N. ‘Sant’Anna e San Sebastiano’, 81100 Caserta, Italy

10. De Gasperis Cardio Center, Niguarda Hospital, 20162 Milano, Italy

11. Cardiothoracic Department, Garibaldi Nesima Hospital, 95122 Catania, Italy

12. Cardiothoracic Department, Maastricht University, 6211 LK Maastrich, The Netherlands

Abstract

Patent foramen ovale (PFO) is a common cardiac abnormality with a prevalence of 25% in the general population. PFO has been associated with the paradoxical embolism causing cryptogenic stroke and systemic embolization. Results from clinical trials, meta-analyses, and position papers support percutaneous PFO device closure (PPFOC), especially if interatrial septal aneurysms coexist and in the presence of large shunts in young patients. Remarkably, accurately evaluating patients to refer to the closure strategy is extremely important. However, the selection of patients for PFO closure is still not so clear. The aim of this review is to update and clarify which patients should be considered for closure treatment.

Publisher

MDPI AG

Subject

General Medicine

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