Giant Juvenile Fibroadenoma: Case Report and Review of the Literature

Author:

Eleftheriades Anna1ORCID,Tsarna Ermioni2ORCID,Toutoudaki Konstantina2,Paschalidou Eleni2,Christopoulos Nikolaos3,Georgopoulos Ioannis3ORCID,Mitropoulou Georgia4,Christopoulos Panagiotis2ORCID

Affiliation:

1. Postgraduate Programme “Maternal Fetal Medicine”, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

2. Second Department of Obstetrics and Gynecology, “Aretaieion” Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece

3. Department of Pediatric Surgery, “Agia Sofia” Children’s Hospital, 11527 Athens, Greece

4. Department of Pathology, “Agia Sofia” Children’s Hospital, 11527 Athens, Greece

Abstract

Fibroadenomas are common benign breast tumors. Fibroadenomas that exceed 5 cm in diameter, weigh more than 500 g, or replace more than four-fifths of the breast are characterized as giant. A fibroadenoma diagnosed in patients during childhood or adolescence is characterized as juvenile. An extensive PubMed search of the literature in English up until August 2022 was performed. In addition, a rare case of a gigantic fibroadenoma in an 11-year-old premenarchal girl who was referred to our adolescent gynecology center is presented here. Eighty-seven cases of giant juvenile fibroadenomas have been reported in the literature along with our case. Patients with giant juvenile fibroadenoma presented at a mean age of 13.92 years and usually after menarche. Juvenile fibroadenomas are usually unilateral, occurring either in the right or the left breast; the majority of them are diagnosed when they are already more than 10 cm in size, and they are most frequently treated with total lump excision. Differential diagnosis includes phyllodes tumors and pseudo-angiomatous stromal hyperplasia. Conservative management is feasible, but surgical excision is recommended to patients with suspicious imaging features or when the mass grows rapidly.

Publisher

MDPI AG

Subject

General Medicine

Reference78 articles.

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3. Harris, J.R., Lippman, M.E., Morrow, M., and Osborne, C.K. (2010). Diseases of the Breast, Wolters Kluwer-Lippincott Williams & Wilkins. [4th ed.].

4. (2021, December 26). Adolescent Health. Available online: https://www.who.int/health-topics/adolescent-health#tab=tab_1.

5. Surgical breast lesions in adolescent females;Tea;Pediatr. Surg. Int.,2008

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