A Specific Tubular ApoA-I Distribution Is Associated to FSGS Recurrence after Kidney Transplantation

Author:

Jacobs-Cachá ConxitaORCID,Puig-Gay NatàliaORCID,Vergara Ander,Gabaldon Maria-Alejandra,Sellarés Joana,Villena-Ortiz YolandaORCID,Agraz IreneORCID,Moreso FrancescORCID,Soler Maria José,Serón DanielORCID,López-Hellín JoanORCID

Abstract

A major complication of primary focal segmental glomerulosclerosis (FSGS) is its recurrence after kidney transplantation that happens in 30 to 40% of the patients. The diagnosis of these relapses is not always easy as the histological lesions are not highly specific and appear after the proteinuria increase. Currently, there are no accurate biomarkers to detect FSGS recurrence. Our group identified a modified form of Apolipoprotein A-I (ApoA-I), named ApoA-Ib, specifically present in the urine of recurrent FSGS patients after kidney transplantation. Aberrant forms of ApoA-I have also been described in the urine of native primary FSGS patients; this feature has been associated with prominent staining of ApoA-I at the apical membrane of the tubular cells. In this study, we aim to analyze the ApoA-I distribution in kidney allograft biopsies of recurrent FSGS patients. We detected ApoA-I by immunohistochemistry in kidney allograft biopsies of patients with FSGS relapse after kidney transplantation and in kidney allograft biopsies of patients with a disease different from FSGS in the native kidney (non-FSGS). In recurrent FSGS patients, ApoA-I was prominently localized at the brush border of the tubular cells, while in the non-FSGS patients, ApoA-I was found along the cytoplasm of the tubular cells. The localization of ApoA-I at the brush border of the tubular cells is a specific feature of primary FSGS in relapse. This suggests that ApoA-I staining in kidney biopsies, coupled with ApoA-Ib measurement in urine, could be used as a diagnostic tool of primary FSGS relapse after kidney transplantation due to its highly specific tubular distribution.

Funder

Instituto de Salud Carlos III

Fundació la Marató de TV3

Publisher

MDPI AG

Subject

General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Urine proteome profile in primary podocytopathies;Nephrology (Saint-Petersburg);2023-03-07

2. Signaling pathways of chronic kidney diseases, implications for therapeutics;Signal Transduction and Targeted Therapy;2022-06-09

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