Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study
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Published:2024-01-22
Issue:1
Volume:14
Page:77
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ISSN:2218-1989
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Container-title:Metabolites
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language:en
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Short-container-title:Metabolites
Author:
Miyake Atsuko12ORCID, Harada Sei1, Sugiyama Daisuke134, Matsumoto Minako1, Hirata Aya1, Miyagawa Naoko1ORCID, Toki Ryota1, Edagawa Shun1, Kuwabara Kazuyo1, Okamura Tomonori14ORCID, Sato Asako5, Amano Kaori5, Hirayama Akiyoshi5ORCID, Sugimoto Masahiro5ORCID, Soga Tomoyoshi5ORCID, Tomita Masaru5, Arakawa Kazuharu5ORCID, Takebayashi Toru14, Iida Miho1
Affiliation:
1. Department of Preventive Medicine and Public Health, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan 2. Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan 3. Faculty of Nursing and Medical Care, Keio University, Kanagawa, Fujisawa 252-0883, Japan 4. Graduate School of Health Management, Keio University, Kanagawa, Fujisawa 252-0883, Japan 5. Institute for Advanced Biosciences, Keio University, Yamagata, Tsuruoka 997-0052, Japan
Abstract
Studies examining long-term longitudinal metabolomic data and their reliability in large-scale populations are limited. Therefore, we aimed to evaluate the reliability of repeated measurements of plasma metabolites in a prospective cohort setting and to explore intra-individual concentration changes at three time points over a 6-year period. The study participants included 2999 individuals (1317 men and 1682 women) from the Tsuruoka Metabolomics Cohort Study, who participated in all three surveys—at baseline, 3 years, and 6 years. In each survey, 94 plasma metabolites were quantified for each individual and quality control (QC) sample. The coefficients of variation of QC, intraclass correlation coefficients, and change rates of QC were calculated for each metabolite, and their reliability was classified into three categories: excellent, fair to good, and poor. Seventy-six percent (71/94) of metabolites were classified as fair to good or better. Of the 39 metabolites grouped as excellent, 29 (74%) in men and 26 (67%) in women showed significant intra-individual changes over 6 years. Overall, our study demonstrated a high degree of reliability for repeated metabolome measurements. Many highly reliable metabolites showed significant changes over the 6-year period, suggesting that repeated longitudinal metabolome measurements are useful for epidemiological studies.
Funder
Yamagata prefectural government city of Tsuruoka Japan Agency for Medical Research and Development Japan Society for the Promotion of Science Ministry of Health, Labor and Welfare, Health and Labor Sciences research grants, Japan
Subject
Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism
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