Genetic Risk Factors for Neurological Disorders in Children with Adverse Events following Immunization: A Descriptive Study of a Polish Case Series
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Published:2023-01-06
Issue:2
Volume:24
Page:1117
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Charzewska AgnieszkaORCID,
Terczyńska Iwona,
Lipiec Agata,
Mazurczak Tomasz,
Górka-Skoczylas Paulina,
Szlendak Róża,
Kanabus Karolina,
Tataj Renata,
Dawidziuk MateuszORCID,
Wojtaś BartoszORCID,
Gielniewski Bartłomiej,
Bal Jerzy,
Stawicka ElżbietaORCID,
Hoffman-Zacharska DorotaORCID
Abstract
Studies conducted on large populations show a lack of connection between vaccination and serious neurological symptoms. However, there are isolated cases that indicate such a relationship. These reports on adverse effects following immunization (AEFI) reduce social confidence in vaccination; however, their background may be rare genetic defects. The aim of the presented study was to examine if neurological AEFI in children may be associated with variants in genes related to neurodevelopment. To identify such possible associations, a descriptive study of the Polish case series was conducted. We performed next-generation sequencing in patients who, up to 4 weeks of injection of any vaccine, manifested neurological AEFI. We included 23 previously normally developing children with first seizures that occurred after vaccination. We identified pathogenic/likely pathogenic variants in genes engaged in neurodevelopment in nine patients and variants of uncertain significance in another nine patients. The mutated genes belonged to the group of genes related to epilepsy syndromes/epileptic encephalopathy. We showed that AEFI might have a genetic background. We hypothesized that in some AEFI patients, the vaccine might only trigger neurological symptoms that would have been manifested anyway as a result of a pathogenic variant in a gene engaged in neurodevelopment.
Funder
Polish National Science Centre
Institute of Mother and Child statutory grants
Polish Minister of Education and Science
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
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