Abstract
In the complex and articulated machinery of the human genome, less than 2% of the transcriptome encodes for proteins, while at least 75% is actively transcribed into non-coding RNAs (ncRNAs). Among the non-coding transcripts, those ≥200 nucleotides long (lncRNAs) are receiving growing attention for their involvement in human diseases, particularly cancer. Genomic studies have revealed the multiplicity of processes, including neoplastic transformation and tumor progression, in which lncRNAs are involved by regulating gene expression at epigenetic, transcriptional, and post-transcriptional levels by mechanism(s) that still need to be clarified. In breast cancer, several lncRNAs were identified and demonstrated to have either oncogenic or tumor-suppressive roles. The functional understanding of the mechanisms of lncRNA action in this disease could represent a potential for translational applications, as these molecules may serve as novel biomarkers of clinical use and potential therapeutic targets. This review highlights the relationship between lncRNAs and the principal hallmark of the luminal breast cancer phenotype, estrogen receptor α (ERα), providing an overview of new potential ways to inhibit estrogenic signaling via this nuclear receptor toward escaping resistance to endocrine therapy.
Funder
Italian Association for Cancer Research
University of Salerno
Regione Campania, Progetto GENOMAeSALUTE
Ministero della Salute
Ministero dell’Università e Ricerca
Fondazione Umberto Veronesi
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference148 articles.
1. Breast cancer intrinsic subtype classification, clinical use and future trends;Dai;Am. J. Cancer Res.,2015
2. The origin of breast tumor heterogeneity;Skibinski;Oncogene,2015
3. Clinical management of breast cancer heterogeneity;Zardavas;Nat. Rev. Clin. Oncol.,2015
4. Distinct steady-state nuclear receptor coregulator complexes exist in vivo;McKenna;Proc. Natl. Acad. Sci. USA,1998
5. Estrogen receptor corepressors—A role in human breast cancer?;Dobrzycka;Endocr. Relat. Cancer,2003
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献