Abstract
Metabolic syndrome (MetSyn) is a precursor for several cardiometabolic diseases such as obesity, type-2 diabetes mellitus (T2DM), and cardiovascular diseases. Emerging evidence suggests that vitamin D deficiency links to cardiometabolic diseases through microbiota. A combination of poor vitamin D status and dysbiosis may contribute to the progression of cardiometabolic diseases. Therefore, in this review, we present the relationship among vitamin D, microbiota, and cardiometabolic diseases with a focus on MetSyn. We searched major databases for reports on vitamin D, microbiota, and MetSyn until June 2022. We reviewed 13 reports on the relation between vitamin D and MetSyn (6 randomized controlled and 7 cross-sectional studies) and 6 reports on the effect of vitamin D on the gut microbiome. Adequate vitamin D status has a beneficial effect on gut microbiota, therefore preventing the progression of MetSyn. Further, well-controlled studies are needed for a better understanding of the mechanisms of action involving vitamin D and microbiota in the pathogenesis of cardiometabolic diseases.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference78 articles.
1. Recommended dietary intakes for vitamin D: Where do they come from, what do they achieve and how can we meet them?;Cashman;J. Hum. Nutr. Diet.,2014
2. Vitamin D and health—The missing vitamin in humans;Chang;Pediatr. Neonatol.,2019
3. Del Valle, H.B., Yaktine, A.L., Taylor, C.L., and Ross, A.C. (2011). Dietary Reference Intakes for Calcium and Vitamin D, National Academies Press.
4. Metabolic syndrome, or What you will: Definitions and epidemiology;Day;Diabetes Vasc. Dis. Res.,2007
5. A comprehensive review on metabolic syndrome;Kaur;Cardiol. Res. Pract.,2014
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献