Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease

Author:

Zhou Tianhao,Kundu Debjyoti,Robles-Linares Jonathan,Meadows Vik,Sato KeisakuORCID,Baiocchi Leonardo,Ekser BurcinORCID,Glaser Shannon,Alpini Gianfranco,Francis Heather,Kennedy Lindsey

Abstract

Fatty liver diseases, such as non-alcoholic fatty liver disease (NAFLD), are global health disparities, particularly in the United States, as a result of cultural eating habits and lifestyle. Pathological studies on NAFLD have been mostly focused on hepatocytes and other inflammatory cell types; however, the impact of other biliary epithelial cells (i.e., cholangiocytes) in the promotion of NAFLD is growing. This review article will discuss how cholestatic injury and cholangiocyte activity/ductular reaction influence NAFLD progression. Furthermore, this review will provide informative details regarding the fundamental properties of cholangiocytes and bile acid signaling that can influence NAFLD. Lastly, studies relating to the pathogenesis of NAFLD, cholangiopathies, and ductular reaction will be analyzed to help gain insight for potential therapies.

Funder

VA

NIH NIDDK

Publisher

MDPI AG

Subject

General Medicine

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