Abstract
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others. Recent data provide compelling evidence that distinct astrocyte states are associated with specific stages of Alzheimer´s disease. The advent of transcriptomics technologies enables rapid progress in the characterisation of such pathological astrocyte states. In this review, we provide an overview of the origin, main functions, molecular and morphological features of astrocytes in physiological as well as pathological conditions related to Alzheimer´s disease. We will also explore the main roles of astrocytes in the pathogenesis of Alzheimer´s disease and summarize main transcriptional changes and altered molecular pathways observed in astrocytes during the course of the disease.
Funder
FEDER/Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación
Reference149 articles.
1. Gesammelte Abhandlungen Zyr Wissenschaftlischen Medizin;Virchow,1856
2. An Early History of Neuroglial Research: Personalities
3. Der Feinere Bau Des Nervensystems Im Lichte Neuester Forschung;von Lenhossék,1895
4. Contribución Al Conocimiento de La Neuroglia Del Cerebro Humano;Ramón y Cajal;Trab. Lab. Invest. Biol. Univ. Madr.,1913
5. Astrocyte development: A Guide for the Perplexed
Cited by
68 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献