Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials-Reference-Cited by-同舟云学术

Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials

Published:2023-12-18 Issue:12 Volume:10 Page:499
ISSN:2308-3425
Container-title:Journal of Cardiovascular Development and Disease
language:en
Short-container-title:JCDD

Author:

Lim Gareth Zigui¹,Lai Jonathan Yexian¹,Seet Christopher Ying Hao¹,Tham Carol Huilian¹,Venketasubramanian Narayanaswamy²^ORCID,Tan Benjamin Yong Qiang³⁴^ORCID,Jing Mingxue³⁴,Yeo Joshua Yee Peng³⁴,Myint May Zin³⁴,Sia Ching-Hui⁴⁵^ORCID,Teoh Hock Luen³⁴,Sharma Vijay Kumar³⁴,Chan Bernard Poon Lap³⁴,Yang Cunli³⁶,Makmur Andrew³⁶^ORCID,Ong Shao Jin³⁶,Yeo Leonard Leong Litt³⁶^ORCID

Affiliation:

1. Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore 308433, Singapore

2. Raffles Neuroscience Centre, Raffles Hospital, Singapore 188770, Singapore

3. Division of Neurology, Department of Medicine, National University Health System, Singapore 119228, Singapore

4. Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore

5. Department of Cardiology, National University Heart Center, Singapore 119228, Singapore

6. Department of Diagnostic Imaging, National University Health System, Singapore 119228, Singapore

Abstract

Endovascular therapy (EVT) has revolutionized the management of acute ischaemic strokes with large vessel occlusion, with emerging evidence suggesting its benefit also in large infarct core volume strokes. In the last two years, four randomised controlled trials have been published on this topic—RESCUE-Japan LIMIT, ANGEL-ASPECT, SELECT2 and TENSION, with overall results showing that EVT improves functional and neurological outcomes compared to medical management alone. This review aims to summarise the recent evidence presented by these four trials and highlight some of the limitations in our current understanding of this topic.

Publisher

MDPI AG

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

https://www.mdpi.com/2308-3425/10/12/499/pdf

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